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Spray Dynamics has been our key partner, helping us achieve the speed, quality, and efficiency we need. Together, we're entering a new world of disease protection.

Mason Kauffman
CEO, US BIOLOGIC
Mouse Pellet Snack

Coated Pellets Eaten by Mice

Coated pellets are eaten by mice, preventing the spread of Lyme disease to ticks, and ultimately to humans.

Spray Dynamics Coating Machine

Spray Dynamics Centrifugal Coater

Spray Dynamics developed a special centrifugal coating applicator for U.S. Biologic. CEO, Mason Kauffman (left) and COO, Steve Zatechka (right).

Controls Screen for Batch Coater

Controls with Touch Screen

Coating parameters are controlled from a simple touch screen.

"We break the supply chain for Lyme disease by vaccinating the mice through a simple coated pellet," explains Mason Kauffman, CEO of US BIOLOGIC. "Mice are the reservoir of the Borrelia burgdorferi bacteria that causes Lyme disease. Ticks get the bacteria from mice and then pass it on to humans." Kauffman says US BIOLOGIC is flipping this scenario to make mice part of the disease prevention solution.

Five years of CDC-sponsored field tests has proved this approach works. Mice developed antibodies to Borrelia burgdorferi after eating pellets coated with the vaccine. In the final year of testing, this reduced tick infection by 76%, meaning fewer ticks could infect humans with Lyme Disease.

Working to obtain USDA approval for the vaccine, US BIOLOGIC faced the challenge of developing and manufacturing the pellets in a form that would be irresistible to mice, environmentally neutral, and hardy enough for distribution outdoors.

"In collaboration with Purina Mills, US BIOLOGIC created a hard acorn-size pellet that contains 100% natural products. "Our goal was to reduce the level of harmful bacteria in the environment while not changing the environmental balance in any way," says Kauffman. "The coated pellet solution has exceeded all expectations." US BIOLOGIC wanted to apply two coatings on the pellets: the vaccine and a weather-resistant outer coating that would be appealing to mice. However, accurate and simultaneous application of these coatings during mass production posed a problem. "We care about speed and output," explained Kauffman, "but more than anything we want every pellet to be perfect."

Company COO, Steve Zatechka, PhD, was responsible for developing a suitable production process. He looked to the food processing industry for assistance and contacted Heat and Control's Spray Dynamics office.

A leading manufacturer of applicators for wet and dry coatings, Spray Dynamics invited Zatechka to its test facility in St. Claire, MO. "It was a good collaborative project from the outset," he recalls. "We brought samples of our pellets and coatings and worked with their engineers to achieve the output and gentleness required for our process. Although they had never built a machine for this type of application, Spray Dynamics developed a centrifugal coater that is quite unique."

"This was a fun and intellectually challenging project," says Doug Hanify, Spray Dynamics' Director of Technology. "We typically apply coatings to food products and also vitamins, and glazes to nutraceuticals," he explains. "The US BIOLOGIC coatings required much tighter specifications and control."

In addition to being temperature sensitive, the liquid vaccine and encapsulation coatings solidify when combined. Hanify says Spray Dynamics' centrifugal batch coater was customized to meet these requirements. In fact, the coating application is so precise, it did not create special cleaning issues beyond the need for an automatic air-purge to keep the encapsulation liquid supply line clear. Rate check set-ups based on pump speed and applicator timing were included to assure coating consistency for each batch cycle.

"Spray Dynamics has been our key partner, helping us achieve the speed, quality, and efficiency we need," says Kauffman. "Together, we're entering a new world of disease protection."

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